Previous studies by others have demonstrated that pterostilbene also has antidiabetic properties. The current study is the first to identify it as a cancer-preventive agent, the researchers report. Their study is tentatively scheduled to appear in the June 19 issue of the Journal of Agricultural and Food Chemistry, a peer-reviewed publication of the American Chemical Society, the world’s largest scientific society.

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It was published on the Web version of the journal on May 10. “The study adds to the growing health benefits of grapes,” said Agnes M. Rimando, Ph.D., lead investigator for the study and a research chemist with the USDA’s Natural Products Utilization Research Unit in Oxford, Miss. The research, limited to laboratory studies of cells, could lead to more healthful varieties of grapes and the design of better drugs to fight cancer and diabetes, two of the major medical problems in this country, says Rimando. However, she cautions that studies will be needed in both animals and humans to evaluate the potential health benefits of pterostilbene, whose biological activities are not well-understood. Prompted by the structural similarity of pterostilbene to resveratrol, Rimando decided to test the compound to determine if it had similar anticancer and antioxidant activities.

In lab tests using mouse mammary cells, pterostilbene prevented a type of cell damage that is normally induced by cancer-causing agents, she says. Earlier studies by the researcher showed that the compound is toxic to a human breast cancer cell line.

The conclusion: It appears that pterostilbene is equal in potency to resveratrol as a cancer-preventive agent, as both have shown similar anticancer activity in lab tests, says Rimando. Their similar effect is likely due to the high antioxidant activity of these compounds, she says. Antioxidants destroy free-radicals, highly reactive molecules whose excess has been linked to cancer. Pterostilbene has another benefit not found in resveratrol. Animal studies by others have shown that the compound can lower blood glucose and may be a potent antidiabetic agent.